What is ChondroFiller?
Chondrofiller is an innovative hydrogel scaffold designed for the repair of focal chondral and osteochondral defects (ICRS Grades 3 and 4). As a minimally invasive option for cartilage regeneration, it empowers orthopaedic surgeons to treat patients effectively with a reliable and streamlined approach.
Mechanism of Action
Chondrofiller works as an advanced solution for cartilage repair by using a specialised collagen Type I hydrogel.
Here’s how it helps regenerate
hyaline-like cartilage:
- Transforms into Hyaline Cartilage:
The collagen Type I hydrogel turns into Type II collagen, mimicking natural cartilage for long-lasting repair. - Encourages Cell Migration:
It promotes chondrocyte (cartilage cell) migration into the defect, helping to rebuild the damaged area. - No Microfracture Needed:
Unlike traditional techniques, Chondrofiller doesn’t require bone perforation, making the procedure less invasive. - Rebuilds the Cartilage Matrix:
Supports the synthesis of cartilage proteins and cell bonding via beta-1 integrins, ensuring strong and stable regeneration.
Key Features, Benefits and Advantageous
Versatile
Chondrofiller is adaptable across a variety of joints, including:
- Small joints (e.g., ankle, shoulder, and finger).
- Larger joints (e.g., knee and hip).
- It supports both arthroscopic and mini-open surgical approaches, making it flexible for different clinical settings.
- It supports both arthroscopic and mini-open surgical approaches, making it flexible for different clinical settings.
- Effective in treating complex cartilage damage in ICRS Grades 3 and 4 lesions.
Easy to use
- The hydrogel formulation is simple to apply and does not require microfracture, making it suitable for defect sizes of 1–3 cm.
- Seamlessly integrates into existing surgical workflows, ensuring an efficient and user-friendly experience for surgeons.
Proven
Chondrofiller delivers consistent and long-term clinical outcomes:
- Demonstrates significant improvements in joint functionality and pain relief, supported by outcomes exceeding five years for chondral and osteochondral lesions.
- Facilitates the formation of hyaline-like cartilage, comparable to more invasive techniques.
- Backed by clinical evidence such as the Breil-Wirth study, which confirms its efficacy in promoting cartilage regeneration.
Retropatellar cartilage defect
Treatment with ChondroFiller liquid against gravity in supine position
Key Features, Benefits and Advantageous
6 months post-ChondroFiller treatment of IV-grade cartilage defects at medial femoral condyle
- Schneider, Ulrich. “Controlled, Randomized Multicenter Study to Compare Compatibility and Safety of ChondroFiller Liquid (Cell Free 2-Component Collagen Gel) with Microfracturing of Patients with Focal Cartilage Defects of the Knee Joint.” Video Journal of Orthopedics Surgery 1 (2016): 1–8. https://doi.org/10.5348/VNP05-2016-1-OA-1.
- Breil-Wirth, Andreas, Lars von Engelhardt, Stefan Lobner, and Jörg Jerosch. “Retrospective Study of Cell-Free Collagen Matrix for Cartilage Repair.” Orthopädische und Unfallchirurgische Praxis 9, no. 515 (2016): 515–520. https://doi.org/10.3238/oup.2016.0515-0520.
- Jerosch, Jörg, and Patrick Joseph. “Mid-Term Results of Regeneration of Articular Cartilage Defects Using Cell-Free Collagen Matrix (ChondroFiller Liquid).” Orthopädische und Unfallchirurgische Praxis 9, no. 109 (2020): 109–115. https://doi.org/10.3238/oup.2019.0109–0115.
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